Xiwen Dai Selected Research

potassium oxonate

1/2021	Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
3/2020	Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
1/2020	Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
11/2019	Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
11/2019	Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.

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Xiwen Dai Research Topics

Disease

6	Hyperuricemia 01/2022 - 11/2019
5	Gout 01/2022 - 11/2019
1	Thrombosis (Thrombus) 08/2021
1	Hemorrhage 08/2021

Drug/Important Bio-Agent (IBA)

6	Uric Acid (Urate)IBA 01/2022 - 11/2019
5	Xanthine OxidaseIBA 01/2022 - 11/2019
5	potassium oxonateIBA 01/2021 - 11/2019
1	Factor XIa (Coagulation Factor XIa)IBA 08/2021
1	EnzymesIBA 01/2021

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2020